quite expensive. While still implemented by CoreCLR, it’s not available in .NET Native and we don’t plan on adding this capability there.
What should I use instead?
AppDomains were used for different purposes. For code isolation, we recommend processes and/or containers. For dynamic loading of assemblies, we recommend the new AssemblyLoadContext class.
Ну и по-мелочи тут ещё https://github.com/dotnet/standard/blob/v2.0.0/docs/faq.md#is-appdomain-part-of-net-standard
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