А, никто не встречался с геном бактерий "fur" ?

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(sci)Berloga Bioinformatics, Biology, etc. Club

А, никто не встречался с геном бактерий "fur" ?

https://en.wikipedia.org/wiki/Ferric_uptake_regulator_family

Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria
https://www.frontiersin.org/articles/10.3389/fcimb.2013.00059/full

In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble ferric iron (Fe3+) and later to defend against reactive oxygen species (ROS) generated by the Fenton chemistry. To acquire Fe3+, bacteria produce low-molecular weight compounds, known as siderophores, which have extremely high affinity for Fe3+. However, during infection the host restricts iron from pathogens by producing iron- and siderophore-chelating proteins, by exporting iron from intracellular pathogen-containing compartments, and by limiting absorption of dietary iron. Ferric Uptake Regulator (Fur) is a transcription factor which utilizes Fe2+ as a corepressor and represses siderophore synthesis in pathogens. Fur, directly or indirectly, controls expression of enzymes that protect against ROS damage. Thus, the challenges of iron homeostasis and defense against ROS are addressed via Fur. Although the role of Fur as a repressor is well-documented, emerging evidence demonstrates that Fur can function as an activator.

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12.06.2023

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Дмитрий · Accepted Answer

Мы пересеклись с этим геном, изучая штаммы бактерий с МКС. Это репрессор генов, отвечающих за траспорт железа. И его активность, видимо, понижена у МКС штаммов, что связано с их гиперустойчивостью к окислительному стрессу. Подробности в приложенной статье.

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А, никто не встречался с геном бактерий "fur" ?

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